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Tolerance and physical dependence are expected physiological responses to prolonged morphine use. Tolerance refers to the need for higher doses to achieve the same analgesic effect, while dependence involves withdrawal symptoms if the medication is abruptly discontinued.

These phenomena differ from addiction, which is characterized by compulsive drug-seeking behavior. Most patients using morphine for medical purposes do not develop addiction.

Gradual dose tapering minimizes withdrawal symptoms such as anxiety, sweating, muscle aches, and gastrointestinal distress. Clinicians plan dose reductions carefully to ensure patient comfort.

Education about tolerance and dependence helps reduce stigma and supports informed decision-making.